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2011 Publications
1. Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi: a double-blind, randomised controlled trial. Ajdukiewicz KM, Cartwright KE, Scarborough M, Mwambene JB, Goodson P, Molyneux ME, Zijlstra EE, French N, Whitty CJ, Lalloo DG. Lancet Infect Dis. 2011:293-300. 2. Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes. Ataíde R, Mwapasa V, Molyneux ME, Meshnick SR, Rogerson SJ. PLoS One. 2011;6:e22491. 3. Keep the focus on contaminated poultry to further curtail New Zealand's campylobacteriosis epidemic. Baker MG, Sears A, Wilson N, French N, Marshall J, Muellner P, Campbell D, van der Logt P, Lake R. N Z Med J. 2011;124:135-9. 4. Reverse Transcriptase drug resistance mutations in HIV-1 Subtype C infected patients on ART in Karonga District, Malawi. Bansode VB, Travers SA, Crampin AC, Ngwira B, French N, Glynn JR, McCormack GP. AIDS Res Ther. 2011;8:38. 5. Redefining cerebral malaria by including malaria retinopathy. Beare NA, Lewallen S, Taylor TE, Molyneux ME. Future Microbiol. 2011:349-55. 6.
Population pharmacokinetics of sulfadoxine and pyrimethamine in Malawian children with malaria. Bell DJ, Nyirongo SK, Mukaka M, Molyneux ME, Winstanley PA, Ward SA. Clin Pharmacol Ther. 2011;89:268-75.
7. Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi. Bruce MC, Macheso A, McConnachie A, Molyneux ME. Malar J. 2011:10:38. 8. The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1. Carrol ED, Payton A, Payne D, Miyajima F, Chaponda M, Mankhambo LA, Banda DL, Molyneux EM, Cox H, Jacobson G, Carr DF, Molyneux ME, Stewart JP, Quinn JP, Hart CA, Ollier WE. J Immunol. 2011;186:2329-35. 9. PCR improves diagnostic yield from lung aspiration in Malawian children with radiologically confirmed pneumonia. Carrol ED, Mankhambo LA, Guiver M, Banda DL; IPD Study Group, Denis B, Dove W, Jeffers G, Molyneux EM, Molyneux ME, Hart CA, Graham SM. PLoS One. 2011;6:e21042.
10. The Uptake and Accuracy of Oral Kits for HIV Self-Testing in High HIV Prevalence Setting: A Cross-Sectional Feasibility Study in Blantyre, Malawi. Choko AT, Desmond N, Webb EL, Chavula K, Napierala-Mavedzenge S, Gaydos CA, Makombe SD, Chunda T, Squire SB, French N, Mwapasa V, Corbett EL. PLoS Med. 2011;8:e1001102.
11. Twelve-monthly versus six-monthly radiological screening for active case-finding of tuberculosis: a randomised controlled trial. Churchyard GJ, Fielding K, Roux S, Corbett EL, Chaisson RE, De Cock KM, Hayes RJ, Grant AD. Thorax. 2011;66:134-9. 12. Test and treat in HIV: success could depend on rapid detection. Cohen T, Corbett EL Lancet. 2011;16:204-6. . 13. Invasive Streptococcus pneumoniae in children, Malawi, 2004-2006. Cornick JE, Everett DB, Broughton C, Denis BB, Banda DL, Carrol ED, Parry CM. Emerg Infect Dis. 2011;17:1107-9. 14. Normal Range of CD4 Cell Counts and Temporal Changes in Two HIVNegative Malawian Populations. Crampin AC, Mwaungulu FD, Ambrose LR, Longwe H, French N. Open AIDS J. 2011;5:74-9. 15. Chest radiography patterns in 75 adolescents with vertically-acquired human immunodeficiency virus (HIV) infection. Desai SR, Copley SJ, Barker RD, Elston CM, Miller RF, Wells AU, Munyati S, Nathoo K, Corbett EL, Ferrand RA Clin Radiol. 2011;66:257-63.
16. Potential Implanon failure in patients on ART. J Duncan S, Hawkins F, Desmond N. Fam Plann Reprod Health Care. 2011;37:59-60. 17. Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia. Dunyo S, Sirugo G, Sesay S, Bisseye C, Njie F, Adiamoh M, Nwakanma D, Diatta M, Janha R, Sisay Joof F, Temple B, Snell P, Conway D, Walton R, Cheung YB, Milligan P. PLoS One. 2011;6:e17371. 18. High transfusion failure rates in Malawian children with severe anaemia following a standard blood transfusion regimen. Esan MO, Phiri KS, Molyneux EM, Mukaka M, Cheema B, Boele van Hensbroek M. Br J Haematol. 2011:4:1365-2141. 19. Ten years of surveillance for invasive Streptococcus pneumoniae during the era of antiretroviral scale-up and cotrimoxazole prophylaxis in Malawi. Everett DB, Mukaka M, Denis B, Gordon SB, Carrol ED, van Oosterhout JJ, Molyneux EM, Molyneux M, French N, Heyderman RS. PLoS One. 2011:6:e17765. 20. Seasonal and geographic differences in treatment-seeking and household cost of febrile illness among children in Malawi. Ewing VL, Lalloo DG, Phiri KS, Roca-Feltrer A, Mangham LJ, SanJoaquin MA. Malar J. 8;10:32.
21. Moxifloxacin and pyrazinamide susceptibility testing in a complex case of multidrug-resistant tuberculosis. Feasey NA, Pond M, Coleman D, Solomon AW, Cosgrove CA, Delgado R, Butcher PD, Mitchison DA, Harrison T. Int J Tuberc Lung Dis. 2011:417-20.
22. Review article: the aetiology, investigation and management of diarrhoea in the HIV-positive patient. Feasey NA, Healey P, Gordon MA. Aliment Pharmacol Ther. 2011;34:587-603. 23. Perception of Risk of Vertically Acquired HIV Infection and Acceptability of Provider-Initiated Testing and Counseling Among Adolescents in Zimbabwe.Ferrand RA, Trigg C, Bandason T, Ndhlovu CE, Mungofa S, Nathoo K, Gibb DM, Cowan FM, Corbett EL. Am J Public Health. 2011.
24. A primary care level algorithm for identifying HIV-infected adolescents in populations at high risk through mother-to-child transmission. Ferrand RA, Weiss HA, Nathoo K, Ndhlovu CE, Mungofa S, Munyati S, Bandason T, Gibb DM, Corbett EL. Trop Med Int Health. 2011;16:349-55. 25. Experimental human pneumococcal carriage models for vaccine research. Ferreira DM, Jambo KC, Gordon SB.Trends Microbiol. 2011;19:464-70. 26. Thibela TB: design and methods of a cluster randomised trial of the effect of community-wide isoniazid preventive therapy on tuberculosis amongst gold miners in South Africa. Fielding KL, Grant AD, Hayes RJ, Chaisson RE, Corbett EL, Churchyard GJ. Contemp Clin Trials. 2011;32:382-92. 27. Voltage-gated, potassium-channel antibody-associated limbic encephalitis presenting as acutepsychosis. Ganguli A, Fitzgerald R, Walker L, Beadsworth M, Mwandumba HC. J Neuropsychiatry Clin Neurosci. 2011 Spring;23:32-4. 28. Development of a standardized screening rule for tuberculosis in people living with HIV in resource-constrained settings: individual participant data meta-analysis of observational studies. Getahun H, Kittikraisak W, Heilig CM, Corbett EL, Ayles H, Cain KP, Grant AD, Churchyard GJ, Kimerling M, Shah S, Lawn SD, Wood R, Maartens G, Granich R, Date AA, Varma JK. PLoS Med. 2011;8:e1000391.
29. Impaired CD4 T Cell Memory Response to Streptococcus pneumoniae Precedes CD4 T Cell Depletion in HIV-Infected Malawian Adults. Glennie SJ, Sepako E, Mzinza D, Harawa V, Miles DJ, Jambo KC, Gordon SB, Williams NA, Heyderman RS PLoS One. 2011;6:e25610.
30. Do multiple concurrent infections in African children cause irreversible immunological damage?Glennie SJ, Nyirenda M, Williams NA, Heyderman RS Immunology 2011. 31. Assessing the validity of sexual behaviour reports in a whole population survey in rural Malawi.Glynn JR, Kayuni N, Banda E, Parrott F, Floyd S, Francis-Chizororo M, Nkhata M, Tanton C, Hemmings J, Molesworth A, Crampin AC, French N. PLoS One. 2011;6:e22840.
32. Impact of human immunodeficiency virus infection on the etiology and outcome of severe pneumonia in Malawian children.Graham SM, Mankhambo L, Phiri A, Kaunda S, Chikaonda T, Mukaka M, Molyneux EM, Carrol ED, Molyneux ME. Pediatr Infect Dis J. 2011:33-8. 33. Primary care practice and health professional determinants of immunisation coverage. Grant CC, Petousis-Harris H, Turner N, Goodyear-Smith F, Kerse N, Jones R, York D, Desmond N, Stewart J J Paediatr Child Health. 2011. 34. Group B Streptococcus and HIV Infection in Pregnant Women, Malawi, 2008-2010. Gray KJ, Kafulafula G, Matemba M, Kamdolozi M, Membe G, French N. Emerg Infect Dis. 2011;10:1932-5. 35. Etiology of suspected pneumonia in adults admitted to a high-dependency unit in Blantyre, Malawi.Hartung TK, Chimbayo D, van Oosterhout JJ, Chikaonda T, van Doornum GJ, Claas EC, Melchers WJ, Molyneux ME, Zijlstra EE. Am J Trop Med Hyg. 2011:105-12. 36. A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells.Herricks T, Seydel KB, Turner G, Molyneux M, Heyderman R, Taylor T, Rathod PK. Lab Chip. 2011: 7;11:2994-3000.
37. Deteriorating Pneumococcal-Specific B-Cell Memory in Minimally Symptomatic African Children with HIV Infection. Iwajomo OH, Finn A, Moons P, Nkhata R, Sepako E, Ogunniyi AD, Williams NA, Heyderman RS. J Infect Dis. 2011;204:534-43.
38. Bronchoalveolar CD4+ T cell responses to respiratory antigens are impaired in HIV-infected adults. Jambo KC, Sepako E, Fullerton DG, Mzinza D, Glennie S, Wright AK, Heyderman RS, Gordon SB. Thorax. 2011;66:375-82.
39. A Framework for the Joint Modeling of Longitudinal Diagnostic Outcome Data and Latent Infection Status: Application to Investigating the Temporal Relationship between Infection and Disease.Jones G, Johnson WO, Vink WD, French N. Biometrics. 2011;10:1541-0420 40. Inhibition of HIV-1 and M-MLV reverse transcriptases by a major polyphenol (3,4,5 tri-O-galloylquinic acid) present in the leaves of the South African resurrection plant, Myrothamnus flabellifolia . Kamng'ona A, Moore JP, Lindsey G, Brandt W. . J Enzyme Inhib Med Chem. 2011. 41. Marked reduction in prevalence of malaria parasitemia and anemia in HIV-infected pregnant women taking cotrimoxazole with or without sulfadoxine-pyrimethamine intermittent preventive therapy during pregnancy in Malawi. Kapito-Tembo A, Meshnick SR, van Hensbroek MB, Phiri K, Fitzgerald M, Mwapasa V. J Infect Dis. 15;203:464-72. 42. - Different regions of hiv-1 subtype c env are associated with placental localization and in utero mother-to-child transmission. Kumar SB, Handelman SK, Voronkin I, Mwapasa V, Janies D, Rogerson SJ, Meshnick SR, Kwiek JJ. J Virol. 2011.
43. Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis.Macfarlane DP, Zou X, Andrew R, Morton NM, Livingstone DE, Aucott RL, Nyirenda MJ, Iredale JP, Walker BR. Am J Physiol Endocrinol Metab. 2011;300:402-9.
44. Feasibility and acceptability of point of care HIV testing in community outreach and GUM drop-in services in the North West of England: A programmatic evaluation. Macpherson P, Chawla A, Jones K, Coffey E, Spaine V, Harrison I, Jelliman P, Phillips-Howard P, Beynon C, Taegtmeyer M. BMC Public Health. 2011;11:419.
45. Stigmatising Attitudes among People Offered Home-Based HIV Testing and Counselling in Blantyre, Malawi: Construction and Analysis of a Stigma Scale. Macpherson P, Webb EL, Choko AT, Desmond N, Chavula K, Napierala Mavedzenge S, Makombe SD, Chunda T, Squire SB, Corbett EL. PLoS One. 2011;6:e26814.
46. Malaria: modification of the red blood cell and consequences in the human host. Moxon CA, Grau GE, Craig AG. Br J Haematol. 2011:1365-2141.
47. The Genetic Bottleneck in Vertical Transmission of Subtype C HIV-1 Is Not Driven by Selection of Especially Neutralization Resistant Virus from the Maternal Viral Population.Russell ES, Kwiek JJ, Keys J, Barton K, Mwapasa V, Montefiori DC, Meshnick SR, Swanstrom R. .J Virol. 2011. 48. A comparison of the National Center for Health Statistics and new World Health Organization growth references for school-age children and adolescents with the use of data from 11 low-income countries.Rousham EK, Roschnik N, Baylon MA, Bobrow EA, Burkhanova M, Campion MG, Adle-Chua T, Degefie T, Hilari C, Kalengamaliro H, Kassa T, Maiga F, Mahumane BJ, Mukaka M, Ouattara F, Parawan AR, Sacko M, Patterson DW, Sobgo G, Khandaker IU, Hall A. Am J Clin Nutr. 2011 ;94:571-7. 49. HIV Type 1 Mutational Patterns in HIV Type 1 Subtype C-Infected Long-Term Survivors in Karonga District Malawi: Further Analysis and Correction. Seager I, Leeson MD, Crampin AC, Mulawa D, French N, Glynn JR, Travers SA, McCormack GP. AIDS Res Hum Retroviruses. 2011. 50. The human transcriptome during nontyphoid Salmonella and HIV coinfection reveals attenuated N FkappaB-mediated inflammation and persistent cell cycle disruption.Schreiber F, Lynn DJ, Houston A, Peters J, Mwafulirwa G, Finlay BB, Brinkman FS, Hancock RE, Heyderman RS, Dougan G, Gordon MA. J Infect Dis. 2011: 15;204:1237-45. 51. A trial of intermittent preventive treatment and home-based management of malaria in a rural area of The Gambia. Sesay S, Milligan P, Touray E, Sowe M, Webb EL, Greenwood BM, Bojang KA. Malar J. 2011;10:2.
52. Correction: circulating soluble endoglin levels in pregnant women in cameroon and Malawi-associations with placental malaria and fetal growth restriction.Silver KL, Conroy AL, Leke RG, Leke RJ, Gwanmesia P, Molyneux ME, Wallace Taylor D, Rogerson SJ, Kain KC. PLoS One. 2011;6:10.1371
53. Prenatal Glucocorticoid Overexposure Causes Permanent Increases in Renal Erythropoietin Expression and Red Blood Cell Mass in the Rat Offspring. Tang JI, Seckl JR, Nyirenda MJ. Endocrinology. 2011. 54. Prenatal overexposure to glucocorticoids programs renal 11β-hydroxysteroid dehydrogenase type 2 expression and salt-sensitive hypertension in the rat. Tang JI, Kenyon CJ, Seckl JR, Nyirenda MJ. J Hypertens. 2011;29:282-9. 55. Correlates of HIV-1 genital shedding in Tanzanian women.Tanton C, Weiss HA, Le Goff J, Changalucha J, Rusizoka M, Baisley K, Everett D, Ross DA, Belec L, Hayes RJ, Watson-Jones D. PLoS One. 2011;6:17480. 56. Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition.Tsilidis KK, Allen NE, Key TJ, Sanjoaquin MA, Bakken K, Berrino F, Fournier A, Lund E, Overvad K, Olsen A, Tjønneland A, Byrnes G, Chajes V, Rinaldi S, Boutron-Ruault MC, Clavel-Chapelon F, Chang-Claude J, Kaaks R, Bergmann M, Boeing H, Koumantaki Y, Palli D, Pala V, Panico S, Tumino R, Vineis P, Bas Bueno-de-Mesquita H, van Duijnhoven FJ, van Gils CH, Peeters PH, Rodríguez L, González CA, Sánchez MJ, Chirlaque MD, Barricarte A, Dorronsoro M, Khaw KT, Rodwell SA, Norat T, Romaguera D, Riboli E. Int J Cancer. 2011;128:1881-9. 57. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Thye T, Vannberg FO, Wong SH, Owusu-Dabo E, Osei I, Gyapong J, Sirugo G, Sisay-Joof F, Enimil A, Chinbuah MA, Floyd S, Warndorff DK, Sichali L, Malema S, Crampin AC, Ngwira B, Teo YY, Small K, Rockett K, Kwiatkowski D, Fine PE, Hill PC, Newport M, Lienhardt C, Adegbola RA, Corrah T, Ziegler A, Morris AP, Meyer CG, Horstmann RD, Hill AV. Nat Genet. 2011;43:1040. 58. - HIV Knowledge Among Canadian-Born and Sub-Saharan African-Born Patients Living with HIV. Tulloch HE, Balfour L, Kowal J, Tasca GA, Angel JB, Garber G, Macpherson P, Cooper C, Cameron DW. J Immigr Minor Health. 2011.
59. Early deaths during tuberculosis treatment are associated with depressed innate responses, bacterial infection, and tuberculosis progression. Waitt CJ, Peter K Banda N, White SA, Kampmann B, Kumwenda J, Heyderman RS, Pirmohamed M, Squire SB. J Infect Dis. 2011;204:358-62.
60. Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF. Wassmer SC, Moxon CA, Taylor T, Grau GE, Molyneux ME, Craig AG. Cell Microbiol. 2011;13:198-209.
61. Liver pathology in Malawian children with fatal encephalopathy. Whitten R, Milner DA Jr, Yeh MM, Kamiza S, Molyneux ME, Taylor TE Hum Pathol. 2011.
62. The prevalence of antimicrobial-resistant Escherichia coli in sympatric wild rodents varies by season and host. Williams NJ, Sherlock C, Jones TR, Clough HE, Telfer SE, Begon M, French N, Hart CA, Bennett M. J Appl Microbiol. 2011;10:1365-2672. 63. Child Neurology Services in Africa. Wilmshurst JM, Badoe E, Wammanda RD, Mallewa M, Kakooza-Mwesige A, Venter A, Newton CR. J Child Neurol. 2011
64. Reduced tuberculosis case notification associated with scaling up antiretroviral treatment in rural Malawi.Zachariah R, Bemelmans M, Akesson A, Gomani P, Phiri K, Isake B, Van den Akker T, Philips M, Mwale A, Gausi F, Kwanjana J, Harries AD. Int J Tuberc Lung Dis. 2011;15:933-7.