Research

Characterising B cell numbers and memory B cells in HIV infected and uninfected Malawian adults.

Longwe H, Gordon S, Malamba R, French N.

BMC Infect Dis. 2010 Sep 22;10(1):280.

Mucosal immunity in resource-limited setting: is the battle ground different?
Glennie SJ, Williams NA, Heyderman RS.
Trends Microbiol. 2010 Sep 8

Second-line treatment in the Malawi antiretroviral programme: high early mortality, but good outcomes in survivors, despite extensive drug resistance at baseline.

Hosseinipour MC, Kumwenda JJ, Weigel R, Brown LB, Mzinganjira D, Mhango B, Eron JJ, Phiri S, van Oosterhout JJ. HIV Med. 2010 Sep;11(8):510-8. Epub 2010 Mar 19

Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi.

Lepesheva GI, Hargrove TY, Anderson S, Kleshchenko Y, Furtak V, Wawrzak Z, Villalta F, Waterman MR. J Biol Chem. 2010 Aug 13;285(33):25582-90. Epub 2010 Jun 8

The risk and timing of tuberculosis diagnosed in smear-negative TB suspects: a 12 month cohort study in Harare, Zimbabwe.
Dimairo M, MacPherson P, Bandason T, Zezai A, Munyati SS, Butterworth AE, Mungofa S, Rusikaniko S, Fielding K, Mason PR, Corbett EL. PLoS One. 2010 Jul 28;5(7):e11849

Favourable one-year ART outcomes in adult Malawians with hepatitis B and C co-infection.
Moore E, Beadsworth MB, Chaponda M, Mhango B, Faragher B, Njala J, Hofland HW, Davies J, Hart IJ, Beeching NJ, Zijlstra EE, van Oosterhout JJ. J Infect. 2010 Jul;61(2):155-63. Epub 2010 May 12

Survey of children accessing HIV services in a high prevalence setting: time for adolescents to count?
Ferrand R, Lowe S, Whande B, Munaiwa L, Langhaug L, Cowan F, Mugurungi O, Gibb D, Munyati S, Williams BG, Corbett EL. Bull World Health Organ. 2010 Jun;88(6):428-34. Epub 2009 Dec 16

Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background.
Noyes HA, Agaba M, Anderson S, Archibald AL, Brass A, Gibson J, Hall L, Hulme H, Oh SJ, Kemp S. BMC Genomics. 2010 Jun 7;11:361

Treatment of glenohumeral osteoarthritis.
Izquierdo R, Voloshin I, Edwards S, Freehill MQ, Stanwood W, Wiater JM, Watters WC 3rd, Goldberg MJ, Keith M, Turkelson CM, Wies JL, Anderson S, Boyer K, Raymond L, Sluka P; American Academy of Orthopedic Surgeons.

J Am Acad Orthop Surg. 2010 Jun;18(6):375-82

Stenotrophomonas maltophilia bacteraemia in 40 haematology patients: risk factors, therapy and outcome.
Chaplow R, Palmer B, Heyderman R, Moppett J, Marks DI.

Bone Marrow Transplant. 2010 Jun;45(6):1109-10. Epub 2009 Oct 5

Malarial retinopathy and fluorescein angiography findings in a Malawian child with cerebral malaria.
Glover SJ, Maude RJ, Taylor TE, Molyneux ME, Beare NA.
Lancet Infect Dis. 2010 Jun;10(6):440

Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition.
Tsilidis KK, Allen NE, Key TJ, Sanjoaquin MA, Bakken K, Berrino F, Fournier A, Lund E, Overvad K, Olsen A, Tjønneland A, Byrnes G, Chajes V, Rinaldi S, Boutron-Ruault MC, Clavel-Chapelon F, Chang-Claude J, Kaaks R, Bergmann M, Boeing H, Koumantaki Y, Palli D, Pala V, Panico S, Tumino R, Vineis P, Bas Bueno-de-Mesquita H, van Duijnhoven FJ, van Gils CH, Peeters PH, Rodríguez L, González CA, Sánchez MJ, Chirlaque MD, Barricarte A, Dorronsoro M, Khaw KT, Rodwell SA, Norat T, Romaguera D, Riboli E.
Int J Cancer. 2010 Jun 9. [Epub ahead of print]

Comparison of genome-wide variation between Malawians and African ancestry HapMap populations.
Joubert BR, North KE, Wang Y, Mwapasa V, Franceschini N, Meshnick SR, Lange EM.
J Hum Genet. 2010 Jun;55(6):366-74. Epub 2010 May 20

Using an improved phagocytosis assay to evaluate the effect of HIV on specific antibodies to pregnancy-associated malaria.
Ataíde R, Hasang W, Wilson DW, Beeson JG, Mwapasa V, Molyneux ME, Meshnick SR, Rogerson SJ. PLoS One. 2010 May 25;5(5):e10807

Are women who work in bars, guesthouses and similar facilities a suitable study population for vaginal microbicide trials in Africa?
Vallely A, Hambleton IR, Kasindi S, Knight L, Francis SC, Chirwa T, Everett D, Shagi C, Cook C, Barberousse C, Watson-Jones D, Changalucha J, Ross D, Hayes RJ; Microbicides Development Programme.
PLoS One. 2010 May 14;5(5):e10661

Long-term impact of acyclovir suppressive therapy on genital and plasma HIV RNA in Tanzanian women: a randomized controlled trial.
Tanton C, Weiss HA, Rusizoka M, Legoff J, Changalucha J, Baisley K, Mugeye K, Everett D, Belec L, Clayton TC, Ross DA, Hayes RJ, Watson-Jones D.
J Infect Dis. 2010 May 1;201(9):1285-97

Var gene expression and human Plasmodium pathogenesis.
Tembo D, Montgomery J.
Future Microbiol. 2010 May;5(5):801-15. Review.

High prevalence of suspected HIV-associated dementia in adult Malawian HIV patients.
Patel VN, Mungwira RG, Tarumbiswa TF, Heikinheimo T, van Oosterhout JJ.
Int J STD AIDS. 2010 May;21(5):356-8

Sex differences in the relationship of regional dopamine release to affect and cognitive function in striatal and extrastriatal regions using positron emission tomography and [(18)F]fallypride.
Riccardi P, Park S, Anderson S, Doop M, Ansari MS, Schmidt D, Baldwin R.
Synapse. 2010 May 26. [Epub ahead of print]

Using an improved phagocytosis assay to evaluate the effect of HIV on specific antibodies to pregnancy-associated malaria.
Ataíde R, Hasang W, Wilson DW, Beeson JG, Mwapasa V, Molyneux ME, Meshnick SR, Rogerson SJ. PLoS One. 2010 May 25;5(5):e10807

Interpreting tuberculin skin tests in a population with a high prevalence of HIV, tuberculosis, and nonspecific tuberculin sensitivity.
Dodd PJ, Millington KA, Ghani AC, Mutsvangwa J, Butterworth AE, Lalvani A, Corbett EL.
Am J Epidemiol. 2010 May 1;171(9):1037-45. Epub 2010 Apr 9

The HIV-associated tuberculosis epidemic--when will we act?
Harries AD, Zachariah R, Corbett EL, Lawn SD, Santos-Filho ET, Chimzizi R, Harrington M, Maher D, Williams BG, De Cock KM.
Lancet. 2010 May 29;375(9729):1906-19. Epub 2010 May 18

Chronic cough and its association with TB-HIV co-infection: factors affecting help-seeking behaviour in Harare, Zimbabwe.
Mavhu W, Dauya E, Bandason T, Munyati S, Cowan FM, Hart G, Corbett EL, Chikovore J.
Trop Med Int Health. 2010 May;15(5):574-9. Epub 2010 Mar 8

Identifying recent Mycobacterium tuberculosis transmission in the setting of high HIV and TB burden.
Mutsvangwa J, Millington KA, Chaka K, Mavhudzi T, Cheung YB, Mason PR, Butterworth AE, Corbett EL, Lalvani A.
Thorax. 2010 Apr;65(4):315-20

HIV decline in Zimbabwe due to reductions in risky sex? Evidence from a comprehensive epidemiological review.
Gregson S, Gonese E, Hallett TB, Taruberekera N, Hargrove JW, Lopman B, Corbett EL, Dorrington R, Dube S, Dehne K, Mugurungi O.
Int J Epidemiol. 2010 Apr 20

Skin disease among human immunodeficiency virus-infected adolescents in Zimbabwe: a strong indicator of underlying HIV infection.
Lowe S, Ferrand RA, Morris-Jones R, Salisbury J, Mangeya N, Dimairo M, Miller RF, Corbett EL.
Pediatr Infect Dis J. 2010 Apr;29(4):346-51

Acute HIV infection among pregnant women in Malawi.
Gay CL, Mwapasa V, Murdoch DM, Kwiek JJ, Fiscus SA, Meshnick SR, Cohen MS.
Diagn Microbiol Infect Dis. 2010 Apr;66(4):356-60

Invasive non-typhoid salmonellae establish systemic intracellular infection in HIV-infected adults: an emerging disease pathogenesis.
Gordon MA, Kankwatira AM, Mwafulirwa G, Walsh AL, Hopkins MJ, Parry CM, Faragher EB, Zijlstra EE, Heyderman RS, Molyneux ME.
Clin Infect Dis. 2010 Apr 1;50(7):953-62.

Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults.
MacLennan CA, Gilchrist JJ, Gordon MA, Cunningham AF, Cobbold M, Goodall M, Kingsley RA, van Oosterhout JJ, Msefula CL, Mandala WL, Leyton DL, Marshall JL, Gondwe EN, Bobat S, López-Macías C, Doffinger R, Henderson IR, Zijlstra EE, Dougan G, Drayson MT, MacLennan IC, Molyneux ME.
Science. 2010 Apr 23;328(5977):508-12.

Neuroimaging findings in children with retinopathy-confirmed cerebral malaria.
Potchen MJ, Birbeck GL, Demarco JK, Kampondeni SD, Beare N, Molyneux ME, Taylor TE.
Eur J Radiol. 2010 Apr;74(1):262-8. Epub 2009 Apr 3

Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.
Auburn S, Fry AE, Clark TG, Campino S, Diakite M, Green A, Richardson A, Jallow M, Sisay-Joof F, Pinder M, Molyneux ME, Taylor TE, Haldar K, Rockett KA, Kwiatkowski DP.
PLoS One. 2010 Apr 1;5(4):e10017

Human immunodeficiency virus (HIV) infection during pregnancy induces CD4 T-cell differentiation and modulates responses to Bacille Calmette-Guérin (BCG) vaccine in HIV-uninfected infants.
Miles DJ, Gadama L, Gumbi A, Nyalo F, Makanani B, Heyderman RS.
Immunology. 2010 Mar;129(3):446-54. Epub 2009 Dec 2

Treatment for lymph node tuberculosis.
Sellar RS, Corbett EL, D'Sa S, Linch DC, Ardeshna KM.
BMJ. 2010 Mar 10;340:c63. doi: 10.1136/bmj.c63

The quest for reciprocal recognition of colonial pharmaceutical qualifications 1896 to 1914.
Anderson S.

A whole genome association study of mother-to-child transmission of HIV in Malawi.
Joubert BR, Lange EM, Franceschini N, Mwapasa V, North KE, Meshnick SR; the NIAID Center for HIV/AIDS Vaccine Immunology.
Genome Med. 2010 Mar 1;2(3):17. [Epub ahead of print]

A trial of a 7-valent pneumococcal conjugate vaccine in HIV-infected adults.
French N, Gordon SB, Mwalukomo T, White SA, Mwafulirwa G, Longwe H, Mwaiponya M, Zijlstra EE, Molyneux ME, Gilks CF.
N Engl J Med. 2010 Mar 4;362(9):812-22.

Importance of antibody and complement for oxidative burst and killing of invasive nontyphoidal Salmonella by blood cells in Africans.
Gondwe EN, Molyneux ME, Goodall M, Graham SM, Mastroeni P, Drayson MT, MacLennan CA.
Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3070-5. Epub 2010 Jan 28

Identification of malaria retinopathy improves the specificity of the clinical diagnosis of cerebral malaria: findings from a prospective cohort study.
Birbeck GL, Beare N, Lewallen S, Glover SJ, Molyneux ME, Kaplan PW, Taylor TE.
Am J Trop Med Hyg. 2010 Feb;82(2):231-4

Potential role for mucosally active vaccines against pneumococcal pneumonia.
Jambo KC, Sepako E, Heyderman RS, Gordon SB.
Trends Microbiol. 2010 Feb;18(2):81-9. Epub 2009 Dec 22. Review

Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi.
Joubert BR, Franceschini N, Mwapasa V, North KE, Meshnick SR.
PLoS One. 2010 Feb 15;5(2):e9212

Prevalence and risk factors for trachoma in central and southern Malawi.
Kalua K, Chirwa T, Kalilani L, Abbenyi S, Mukaka M, Bailey R.
PLoS One. 2010 Feb 5;5(2):e9067

Reliability of rapid testing for hepatitis B in a region of high HIV endemicity.
Davies J, van Oosterhout JJ, Nyirenda M, Bowden J, Moore E, Hart IJ, Zijlstra EE, Chaponda M, Faragher B, Beeching NJ, Beadsworth MB.
Trans R Soc Trop Med Hyg. 2010 Feb;104(2):162-4

Is HIV-associated tuberculosis a risk factor for the development of cryptococcal disease?
Jarvis JN, Harrison TS, Corbett EL, Wood R, Lawn SD.
AIDS. 2010 Feb 20;24(4):612-4

Causes of acute hospitalization in adolescence: burden and spectrum of HIV-related morbidity in a country with an early-onset and severe HIV epidemic: a prospective survey.
Ferrand RA, Bandason T, Musvaire P, Larke N, Nathoo K, Mujuru H, Ndhlovu CE, Munyati S, Cowan FM, Gibb DM, Corbett EL.
PLoS Med. 2010 Feb 2;7(2):e1000178

Provider-initiated symptom screening for tuberculosis in Zimbabwe: diagnostic value and the effect of HIV status.
Corbett EL, Zezai A, Cheung YB, Bandason T, Dauya E, Munyati SS, Butterworth AE, Rusikaniko S, Churchyard GJ, Mungofa S, Hayes RJ, Mason PR.
Bull World Health Organ. 2010 Jan;88(1):13-21

Lymphocyte subsets in healthy Malawians: implications for immunologic assessment of HIV infection in Africa.
Mandala WL, MacLennan JM, Gondwe EN, Ward SA, Molyneux ME, MacLennan CA.
J Allergy Clin Immunol. 2010 Jan;125(1):203-8. Epub 2009 Nov 26

Diagnosis and management of antiretroviral-therapy failure in resource-limited settings in sub-Saharan Africa: challenges and perspectives.
Harries AD, Zachariah R, van Oosterhout JJ, Reid SD, Hosseinipour MC, Arendt V, Chirwa Z, Jahn A, Schouten EJ, Kamoto K.
Lancet Infect Dis. 2010 Jan;10(1):60-5